Acne Scars

Scand Cardiovasc J. 2009 May 13; 1-9Patila T, Ikonen T, Kankuri E, Ahonen A, Krogerus L, Lauerma K, Harjula AObjectives. We aimed to assess the spontaneous healing of myocardial function after occlusion of a chronically stenosed coronary vessel in a porcine model. Design. Ischemia and infarction was produced by Ameroid constrictor placement and a subsequent ligation of the left circumflex artery. Cardiac MRI and 18FDG-PET were performed one and five weeks later. Ki67 staining was used to identify proliferating cells. Results. Restoration of perfusion defect was detected by MRI (p = 0.0065), reduced systolic function of the lateral segment spontaneously recovered (p = 0.03). There was also a suggestive raise in impaired ejection fraction (p = 0.06). Left ventricular early diastolic filling and peak filling rate were substantially improved (p = 0.039 and p = 0.0078). Scar size reduced (p = 0.03). On the 18FDG-PET, deranged metabolism was alleviated (p = 0.03). Cardiomyocytes with positive Ki-67 staining were located principally in the non-infarcted myocardium as compared to the infarction or border areas (p = 0.037). Conclusions. We demonstrated spontaneous functional healing of ischemic and infarcted left ventricle, suggesting border zone perfusion recovery. Scar reduction was detected. Different pattern of myocyte proliferation between infarction and non-ischemic myocardium was seen.